Recent developments in using mechanistic cardiac modelling for drug safety evaluation
نویسندگان
چکیده
منابع مشابه
Recent developments in using mechanistic cardiac modelling for drug safety evaluation
On the tenth anniversary of two key International Conference on Harmonisation (ICH) guidelines relating to cardiac proarrhythmic safety, an initiative aims to consider the implementation of a new paradigm that combines in vitro and in silico technologies to improve risk assessment. The Comprehensive In Vitro Proarrhythmia Assay (CiPA) initiative (co-sponsored by the Cardiac Safety Research Cons...
متن کاملRecent Developments in Cardiac Surgery
The scope of cardiac surgery is continually changing. Operations such as those' 'n mitral stenosis, patent ductus arteriosus and coarctation of the aorta are now established. These cases rarely require special investigation and have passed into1 routine list of any general surgeon who is familiar with the conduct of thoracotof and its complications. Other operations are made possible by the use...
متن کاملRecent Developments in Intensive Cardiac Care for Acute Cardiac Disorders
emergencies that can develop into rapidly evolving life-threatening situations requiring efficient and rapid interventions. In its original concept, the CCU was designed for arrhythmia monitoring and treatment of patients with acute coronary syndromes. In present scenario, the CCU has evolved into a critical care environment that delivers care both to patients with acute single-system cardiovas...
متن کاملCardiac allograft vasculopathy: recent developments.
Cardiac allograft vasculopathy (CAV) continues to limit the long-term success of cardiac transplantation. Recent insights have underscored the fact that innate and adaptive immune responses are involved in the pathogenesis of CAV. Vascular lesions are the result of cumulative endothelial injuries induced both by alloimmune responses and by nonspecific insults (including ischemia-reperfusion inj...
متن کاملRecent Developments in OCL and Textual Modelling
The panel session of the 16th OCL workshop featured a lightning talk session for discussing recent developments and open questions in the area of OCL and textual modelling. During this session, the OCL community discussed, stimulated through short presentations by OCL experts, tool support, potential future extensions, and suggested initiatives to make the textual modelling community even more ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Drug Discovery Today
سال: 2016
ISSN: 1359-6446
DOI: 10.1016/j.drudis.2016.02.003